Article
Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapy.
The Journal of clinical endocrinology and metabolism - 1 Nov 2005
Appelhof Bente C, Peeters Robin P, Wiersinga Wilmar M, Visser Theo J, Wekking Ellie M, Huyser Jochanan, Schene Aart H, Tijssen Jan G P, Hoogendijk Witte J G, Fliers Eric
Abstract excerpt
INTRODUCTION: Some patients on levothyroxine replacement display significant impairment in psychological well-being, compared with sex- and age-matched controls. Levothyroxine-treated patients can be assumed to derive T3 exclusively from deiodination of T4, which, in the central nervous system, is regulated by type II deiodinase (DII). OBJECTIVE: We investigated whether two recently identified polymorphisms in...
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