Article
Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease.
Respiratory research - 2 May 2017
Weidner Julie, Jarenbäck Linnea, de Jong Kim, Vonk Judith M, van den Berge Maarten, Brandsma Corry-Anke, Boezen H Marike, Sin Don, Bossé Yohan, Nickle David, Ankerst Jaro, Bjermer Leif, Postma Dirkje S, Faiz Alen, Tufvesson Ellen
Abstract excerpt
BACKGROUND: It has been observed that mice lacking the sulfatase modifying factor (Sumf1) developed an emphysema-like phenotype. However, it is unknown if SUMF1 may play a role in Chronic Obstructive Pulmonary Disease (COPD) in humans. The aim was to investigate if the expression and genetic regulation of SUMF1 differs between smokers with and without COPD. METHODS: SUMF1 mRNA was investigated in sputum cells and...
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