Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.

doi:10.1165/rcmb.2016-0172OC

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Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.

American journal of respiratory cell and molecular biology - 1 Mar 2017

Hardin Megan, Cho Michael H, Sharma Sunita, Glass Kimberly, Castaldi Peter J, McDonald Merry-Lynn, Aschard Hugues, Senter-Sylvia Jody, Tantisira Kelan, Weiss Scott T, Hersh Craig P, Morrow Jarrett D, Lomas David, Agusti Alvar, Bakke Per, Gulsvik Amund, O'Connor George T, Dupuis Josée, Hokanson John, Crapo James D, Beaty Terri H, Laird Nan, Silverman Edwin K, DeMeo Dawn L

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a complex disease with strong environmental and genetic influences and sexually dimorphic features. Although genetic risk factors for COPD have been identified, much of the heritability remains unexplained. Sex-based genetic association studies may uncover additional COPD genetic risk factors. We studied current and former smokers from COPD case-control cohorts...

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Identifiers

PMID: 27854507
DOI: 10.1165/rcmb.2016-0172OC
PMCID: PMC5359539

Genes

CELSR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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