Article
Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.
Disease markers - 1 Jan 2017
Beaney Katherine E, Smith Andrew J P, Folkersen Lasse, Palmen Jutta, Wannamethee S Goya, Jefferis Barbara J, Whincup Peter, Gaunt Tom R, Casas Juan P, Ben-Shlomo Yoav, Price Jacqueline F, Kumari Meena, Wong Andrew, Ong Ken, Hardy Rebecca, Kuh Diana, Wareham Nicholas, Kivimaki Mika, Eriksson Per, Humphries Steve E, Consortium Ucleb
Abstract excerpt
Background. The coronary heart disease (CHD) risk locus on 21q22 (lead SNP rs9982601) lies within a "gene desert." The aim of this study was to assess if this locus is associated with CHD risk factors and to identify the functional variant(s) and gene(s) involved. Methods. A phenome scan was performed with UCLEB Consortium data. Allele-specific protein binding was studied using electrophoretic mobility shift...
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