Article
Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus.
PLoS genetics - 1 Jan 2013
Miller Clint L, Anderson D Ryan, Kundu Ramendra K, Raiesdana Azad, Nürnberg Sylvia T, Diaz Roxanne, Cheng Karen, Leeper Nicholas J, Chen Chung-Hsing, Chang I-Shou, Schadt Eric E, Hsiung Chao Agnes, Assimes Themistocles L, Quertermous Thomas
Abstract excerpt
Coronary heart disease (CHD) is the leading cause of mortality in both developed and developing countries worldwide. Genome-wide association studies (GWAS) have now identified 46 independent susceptibility loci for CHD, however, the biological and disease-relevant mechanisms for these associations remain elusive. The large-scale meta-analysis of GWAS recently identified in Caucasians a CHD-associated locus at...
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