Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

doi:10.1371/journal.pgen.1004263

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

PLoS genetics - 1 Mar 2014

Miller Clint L, Haas Ulrike, Diaz Roxanne, Leeper Nicholas J, Kundu Ramendra K, Patlolla Bhagat, Assimes Themistocles L, Kaiser Frank J, Perisic Ljubica, Hedin Ulf, Maegdefessel Lars, Schunkert Heribert, Erdmann Jeanette, Quertermous Thomas, Sczakiel Georg

Abstract excerpt

Genome-wide association studies (GWAS) have identified chromosomal loci that affect risk of coronary heart disease (CHD) independent of classical risk factors. One such association signal has been identified at 6q23.2 in both Caucasians and East Asians. The lead CHD-associated polymorphism in this region, rs12190287, resides in the 3' untranslated region (3'-UTR) of TCF21, a basic-helix-loop-helix transcription...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Basic Helix-Loop-Helix Transcription Factors

Share to Binding Sites

Share to Cell Differentiation

Share to Chromosomes, Human, Pair 6

Share to Coronary Disease

Share to Gene Expression Regulation

Share to MicroRNAs

Source

Open in PubMed Open full text

Identifiers

PMID: 24676100
DOI: 10.1371/journal.pgen.1004263
PMCID: PMC3967965

Genes

TCF21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.PMID 24676100Read ↗

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci.Semantic proximity Read ↗

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease riskSemantic proximity Read ↗

Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.Semantic proximity Read ↗

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cellsSemantic proximity Read ↗

TCF21 rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population.Semantic proximity Read ↗

Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction.Semantic proximity Read ↗

Association of a transcription factor 21 gene polymorphism with hypertensionSemantic proximity Read ↗

Coronary Disease-Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway.Semantic proximity Read ↗

TCF21 genetic polymorphisms and breast cancer risk in Chinese women.Semantic proximity Read ↗

The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.