Article
Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2015
Brænne Ingrid, Civelek Mete, Vilne Baiba, Di Narzo Antonio, Johnson Andrew D, Zhao Yuqi, Reiz Benedikt, Codoni Veronica, Webb Thomas R, Foroughi Asl Hassan, Hamby Stephen E, Zeng Lingyao, Trégouët David-Alexandre, Hao Ke, Topol Eric J, Schadt Eric E, Yang Xia, Samani Nilesh J, Björkegren Johan L M, Erdmann Jeanette, Schunkert Heribert, Lusis Aldons J
Abstract excerpt
OBJECTIVE: Genome-wide association studies have to date identified 159 significant and suggestive loci for coronary artery disease (CAD). We now report comprehensive bioinformatics analyses of sequence variation in these loci to predict candidate causal genes. APPROACH AND RESULTS: All annotated genes in the loci were evaluated with respect to protein-coding single-nucleotide polymorphism and gene expression...
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