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Article

Alternative zippering as an on-off switch for SNARE-mediated fusion.

Science (New York, N.Y.) - 23 Jan 2009

Giraudo Claudio G, Garcia-Diaz Alejandro, Eng William S, Chen Yuhang, Hendrickson Wayne A, Melia Thomas J, Rothman James E

Abstract excerpt

Membrane fusion between vesicles and target membranes involves the zippering of a four-helix bundle generated by constituent helices derived from target- and vesicle-soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). In neurons, the protein complexin clamps otherwise spontaneous fusion by SNARE proteins, allowing neurotransmitters and other mediators to be secreted when and where...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19164750
DOI: 10.1126/science.1166500
PMCID: PMC3736854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alternative zippering as an on-off switch for SNARE-mediated fusion.PMID 19164750Read ↗

Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion.Semantic proximity Read ↗

Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.Semantic proximity Read ↗

The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.Semantic proximity Read ↗

SNARE interactions in membrane trafficking: a perspective from mammalian central synapses.Semantic proximity Read ↗

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.Semantic proximity Read ↗

Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion.Semantic proximity Read ↗

Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.Semantic proximity Read ↗

Conserved prefusion protein assembly in regulated exocytosis.Semantic proximity Read ↗

SNARE complex formation is triggered by Ca2+ and drives membrane fusion.Semantic proximity Read ↗

Trans-SNARE pairing can precede a hemifusion intermediate in intracellular membrane fusion.Semantic proximity Read ↗

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms.Semantic proximity Read ↗

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis.Semantic proximity Read ↗

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