The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.

doi:10.1016/j.tube.2017.02.005

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Article

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.

Tuberculosis (Edinburgh, Scotland) - 1 May 2017

Graustein Andrew D, Horne David J, Fong Jerry J, Schwarz Flavio, Mefford Heather C, Peterson Glenna J, Wells Richard D, Musvosvi Munyaradzi, Shey Muki, Hanekom Willem A, Hatherill Mark, Scriba Thomas J, Thuong Nguyen Thuy Thuong, Mai Nguyen Thi Hoang, Caws Maxine, Bang Nguyen Duc, Dunstan Sarah J, Thwaites Guy E, Varki Ajit, Angata Takashi, Hawn Thomas R

Abstract excerpt

Humans exposed to Mycobacterium tuberculosis (Mtb) have variable susceptibility to tuberculosis (TB) and its outcomes. Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains. The SIGLEC14 coding sequence is deleted in a high proportion of individuals, placing a SIGLEC5-like gene under...

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Identifiers

PMID: 28454648
DOI: 10.1016/j.tube.2017.02.005
PMCID: PMC7289319

Genes

SIGLEC14
SIGLEC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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