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Deletion polymorphism of SIGLEC14 and its functional implications

15 Apr 2009

Abstract excerpt

Human Siglec-14, a member of the Siglec family of sialic acid-binding lectins, shows extensive sequence similarity to human Siglec-5. To analyze respective expression patterns of Siglec-14 and Siglec-5, we developed specific antibodies against each of them. We found that the former was expressed on granulocytes and monocytes, while the latter was on granulocytes and B-cells. Surprisingly, some individuals lacked...

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PMID: 19369701
DOI: 10.1093/glycob/cwp052

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