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Article

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

The Journal of experimental medicine - 2 Jun 2014

Ali Syed Raza, Fong Jerry J, Carlin Aaron F, Busch Tamara D, Linden Rebecka, Angata Takashi, Areschoug Thomas, Parast Mana, Varki Nissi, Murray Jeffrey, Nizet Victor, Varki Ajit

Abstract excerpt

Group B Streptococcus (GBS) causes invasive infections in human newborns. We recently showed that the GBS β-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes. Interestingly, neutrophils and monocytes also express Siglec-14, which has a ligand-binding domain almost identical to Siglec-5 but signals via an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24799499
DOI: 10.1084/jem.20131853
PMCID: PMC4042635

Genes

SIGLEC14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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