Article
SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.
European journal of immunology - 1 Aug 2008
Cao Huan, Lakner Ursula, de Bono Bernard, Traherne James A, Trowsdale John, Barrow Alexander D
Abstract excerpt
Sialic acid binding immunoglobulin-like lectins (Siglec) are important components of immune recognition. The organization of Siglec genes in different species is consistent with rapid selection imposed by pathogens. We studied SIGLEC11 genes in human, rodent, dog, cow and non-human primates. The...
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