Article
Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance.
Genome biology - 28 Apr 2017
Cerqueira Gustavo C, Cheeseman Ian H, Schaffner Steve F, Nair Shalini, McDew-White Marina, Phyo Aung Pyae, Ashley Elizabeth A, Melnikov Alexandre, Rogov Peter, Birren Bruce W, Nosten François, Anderson Timothy J C, Neafsey Daniel E
Abstract excerpt
BACKGROUND: Artemisinin-based combination therapies are the first line of treatment for Plasmodium falciparum infections worldwide, but artemisinin resistance has risen rapidly in Southeast Asia over the past decade. Mutations in the kelch13 gene have been implicated in this resistance. We used longitudinal genomic surveillance to detect signals in kelch13 and other loci that contribute to artemisinin or partner...
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