Article
A major genome region underlying artemisinin resistance in malaria.
Science (New York, N.Y.) - 6 Apr 2012
Cheeseman Ian H, Miller Becky A, Nair Shalini, Nkhoma Standwell, Tan Asako, Tan John C, Al Saai Salma, Phyo Aung Pyae, Moo Carit Ler, Lwin Khin Maung, McGready Rose, Ashley Elizabeth, Imwong Mallika, Stepniewska Kasia, Yi Poravuth, Dondorp Arjen M, Mayxay Mayfong, Newton Paul N, White Nicholas J, Nosten François, Ferdig Michael T, Anderson Timothy J C
Abstract excerpt
Evolving resistance to artemisinin-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy to identify genome region(s) underlying this ongoing selective...
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