Article
Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly.
Science (New York, N.Y.) - 28 Apr 2017
Mountoufaris George, Chen Weisheng V, Hirabayashi Yusuke, O'Keeffe Sean, Chevee Maxime, Nwakeze Chiamaka L, Polleux Franck, Maniatis Tom
Abstract excerpt
The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Here, we show that all three gene clusters functionally cooperate to provide individual mouse olfactory sensory neurons (OSNs) with the cell surface diversity required for their assembly into distinct glomeruli in the olfactory bulb. Although deletion of individual Pcdh...
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