Article
Gamma protocadherins are required for synaptic development in the spinal cord.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2005
Weiner Joshua A, Wang Xiaozhong, Tapia Juan Carlos, Sanes Joshua R
Abstract excerpt
Fifty-eight cadherin-related protocadherin (Pcdh) genes are tandemly arrayed in three clusters (alpha, beta, and gamma) on mouse chromosome 18. The large number of clustered Pcdh family members, their presence at synapses, and the known binding specificities of other cadherin superfamily members all suggest that these Pcdhs play roles in specifying synaptic connectivity. Consistent with this idea, mice lacking...
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