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The role of macrophage TAM receptor family in the acute‐to‐chronic progression of liver disease: From friend to foe?

28 Jul 2022

Abstract excerpt

Hepatic macrophages, the key cellular components of the liver, emerge as essential players in liver inflammation, tissue repair and subsequent fibrosis, as well as tumorigenesis. Recently, the TAM receptor tyrosine kinase family, consisting of Tyro3, Axl and MerTK, was found to be a pivotal modulator of macrophages. Activation of macrophage TAM receptor signalling promotes the efferocytosis of apoptotic cells and...

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PMID: 35900248
DOI: 10.1111/liv.15380

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