Article
Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background.
Neuroscience - 23 Jun 2017
Farkas József, Kovács László Á, Gáspár László, Nafz Anna, Gaszner Tamás, Ujvári Balázs, Kormos Viktória, Csernus Valér, Hashimoto Hitoshi, Reglődi Dóra, Gaszner Balázs
Abstract excerpt
Major depression is a common cause of chronic disability. Despite decades of efforts, no equivocally accepted animal model is available for studying depression. We tested the validity of a new model based on the three-hit concept of vulnerability and resilience. Genetic predisposition (hit 1, mutation of pituitary adenylate cyclase-activating polypeptide, PACAP gene), early-life adversity (hit 2, 180-min maternal...
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