Article
A mouse model of the 3-hit effects of stress: Genotype controls the effects of life adversities in females.
Progress in neuro-psychopharmacology & biological psychiatry - 20 Dec 2023
Babicola Lucy, Mancini Camilla, Riccelli Cristina, Di Segni Matteo, Passeri Alice, Municchi Diana, D'Addario Sebastian Luca, Andolina Diego, Cifani Carlo, Cabib Simona, Ventura Rossella
Abstract excerpt
Helplessness is a dysfunctional coping response to stressors associated with different psychiatric conditions. The present study tested the hypothesis that early and adult adversities cumulate to produce helplessness depending on the genotype (3-hit hypothesis of psychopathology). To this aim, we evaluated whether Chronic Unpredictable Stress (CUS) differently affected coping and mesoaccumbens dopamine (DA)...
Topics
- Female
- Animals
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Disease Models, Animal
- Genotype
- Phenotype
- Dopamine