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Article

A mouse model of the 3-hit effects of stress: Genotype controls the effects of life adversities in females.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Dec 2023

Babicola Lucy, Mancini Camilla, Riccelli Cristina, Di Segni Matteo, Passeri Alice, Municchi Diana, D'Addario Sebastian Luca, Andolina Diego, Cifani Carlo, Cabib Simona, Ventura Rossella

Abstract excerpt

Helplessness is a dysfunctional coping response to stressors associated with different psychiatric conditions. The present study tested the hypothesis that early and adult adversities cumulate to produce helplessness depending on the genotype (3-hit hypothesis of psychopathology). To this aim, we evaluated whether Chronic Unpredictable Stress (CUS) differently affected coping and mesoaccumbens dopamine (DA)...

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PMID: 37611651
DOI: 10.1016/j.pnpbp.2023.110842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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