Article
FireProt: web server for automated design of thermostable proteins.
Nucleic acids research - 3 Jul 2017
Musil Milos, Stourac Jan, Bendl Jaroslav, Brezovsky Jan, Prokop Zbynek, Zendulka Jaroslav, Martinek Tomas, Bednar David, Damborsky Jiri
Abstract excerpt
There is a continuous interest in increasing proteins stability to enhance their usability in numerous biomedical and biotechnological applications. A number of in silico tools for the prediction of the effect of mutations on protein stability have been developed recently. However, only single-point mutations with a small effect on protein stability are typically predicted with the existing tools and have to be...
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