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Article

PROTS-RF: a robust model for predicting mutation-induced protein stability changes.

PloS one - 1 Jan 2012

Li Yunqi, Fang Jianwen

Abstract excerpt

The ability to improve protein thermostability via protein engineering is of great scientific interest and also has significant practical value. In this report we present PROTS-RF, a robust model based on the Random Forest algorithm capable of predicting thermostability changes induced by not only single-, but also double- or multiple-point mutations. The model is built using 41 features including evolutionary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23077576
DOI: 10.1371/journal.pone.0047247
PMCID: PMC3471942

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