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Article

Predicting protein thermostability changes from sequence upon multiple mutations.

Bioinformatics (Oxford, England) - 1 Jul 2008

Montanucci Ludovica, Fariselli Piero, Martelli Pier Luigi, Casadio Rita

Abstract excerpt

MOTIVATION: A basic question in protein science is to which extent mutations affect protein thermostability. This knowledge would be particularly relevant for engineering thermostable enzymes. In several experimental approaches, this issue has been serendipitously addressed. It would be therefore convenient providing a computational method that predicts when a given protein mutant is more thermostable than its...

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Identifiers

PMID: 18586713
DOI: 10.1093/bioinformatics/btn166
PMCID: PMC2718644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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