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Article

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability.

Nature communications - 26 Apr 2017

Wang Xiangxi, Li Shi-Hua, Zhu Ling, Nian Qing-Gong, Yuan Shuai, Gao Qiang, Hu Zhongyu, Ye Qing, Li Xiao-Feng, Xie Dong-Yang, Shaw Neil, Wang Junzhi, Walter Thomas S, Huiskonen Juha T, Fry Elizabeth E, Qin Cheng-Feng, Stuart David I, Rao Zihe

Abstract excerpt

Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths each year in Asia. The structural and molecular basis of this encephalitis is not fully understood. Here, we report the cryo-electron microscopy structure of mature Japanese encephalitis virus at near-atomic resolution, which reveals an unusual "hole" on...

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Identifiers

PMID: 28446752
DOI: 10.1038/s41467-017-00024-6
PMCID: PMC5432033

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