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Isolation and Transcriptomic Characterization of Genotype 5 Japanese Encephalitis Virus E138K Mutant Strain.

Transboundary and emerging diseases - 1 Jan 2026

Yang Yuhong, Wang Ruichen, Zhang Weijia, Yin Qikai, Li Fan, Fu Shihong, Nie Kai, Cui Qianqian, Xu Songtao, Wang Huanyu

Abstract excerpt

The recent emergence of the genotype five Japanese encephalitis virus (G5 JEV) has once again drawn public attention to public health concerns. Plaque assay analysis of G5 JEV parental strain XZ0934 revealed two distinct plaque morphologies. To investigate this phenotypic heterogeneity, we performed single-plaque purification and isolated two strains, designated as XZ0934-L (large plaque) and XZ0934-S (small...

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PMID: 42147454
DOI: 10.1155/tbed/9733265
PMCID: PMC13173371

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