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Article

Acidity/Alkalinity of Japanese Encephalitis Virus E Protein Residue 138 Alters Neurovirulence in Mice.

Journal of virology - 15 Nov 2018

Zheng Xuchen, Zheng Hao, Tong Wu, Li Guoxin, Wang Tao, Li Liwei, Gao Fei, Shan Tongling, Yu Hai, Zhou Yanjun, Qiu Yafeng, Ma Zhiyong, Tong Guangzhi

Abstract excerpt

The Japanese encephalitis virus (JEV) envelope (E) protein, as one of mediators of virus entry into host cells, plays a critical role in determining virulence. The Glu-to-Lys mutation of residue 138 in E protein (E138) plays an important role in attenuating JEV vaccine strain SA14-14-2. However, it is not clear how E138 attenuates JEV. Here, we demonstrate that the Glu-to-Arg mutation of E138 also determines the...

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Identifiers

PMID: 30158291
DOI: 10.1128/JVI.00108-18
PMCID: PMC6206487

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