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Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses

26 Feb 2021

Abstract excerpt

Enteroviruses pose a persistent and widespread threat to human physical health, with no specific treatments available. Small molecule capsid binders have the potential to be developed as antivirals that prevent virus attachment and entry into host cells. To aid with broad-range drug development, we report here structures of coxsackieviruses B3 and B4 bound to different interprotomer-targeting capsid binders using...

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PMID: 33637854
DOI: 10.1038/s42003-021-01779-x

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