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Article

The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes.

Nature communications - 10 Aug 2024

Cao Duanfang, Ma Bingting, Cao Ziyi, Xu Xiaoyu, Zhang Xinzheng, Xiang Ye

Abstract excerpt

Eastern Equine Encephalitis virus (EEEV) is an alphavirus that can cause severe diseases in infected humans. The very low-density lipoprotein receptor (VLDLR) was recently identified as a receptor of EEEV. Herein, we performed cryo-electron microscopy structural and biochemistry studies on the specific interactions between EEEV and VLDLR. Our results show that VLDLR binds EEEV at three different sites A, B and C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39127734
DOI: 10.1038/s41467-024-51293-x
PMCID: PMC11316819

Genes

VLDLR
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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