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Article

Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure

10 Dec 2018

Abstract excerpt

Alphaviruses are enveloped RNA viruses that contain several human pathogens. Due to intrinsic heterogeneity of alphavirus particles, a high resolution structure of the virion is currently lacking. Here we provide a 3.5 Å cryo-EM structure of Sindbis virus, using block based reconstruction method that overcomes the heterogeneity problem. Our structural analysis identifies a number of conserved residues that play...

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PMID: 30552337
DOI: 10.1038/s41467-018-07704-x

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