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Article

DNA-induced 2′3′-cGAMP enhances haplotype-specific human STING cleavage by dengue protease

23 Jun 2020

Abstract excerpt

The cytosolic DNA sensor cGMP-AMP synthase (cGAS) synthesizes the noncanonical cyclic dinucleotide 2'3'-cGAMP to activate the adaptor protein stimulator of IFN genes (STING), thus awakening host immunity in response to DNA pathogen infection. However, dengue virus (DENV), an RNA virus without a DNA stage in its life cycle, also manipulates cGAS-STING-mediated innate immunity by proteolytic degradation of STING....

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PMID: 32576686
DOI: 10.1073/pnas.1922243117

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