Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Characteristics and Clinical Significance of CRLF2 Mutations in Adult Acute Lymphoblastic Leukemia].

Zhongguo shi yan xue ye xue za zhi - 1 Apr 2017

Gu Yan, Wu Yu-Jie, Han Qi, Zhou Xi-Lian, Qiao Chun, Li Jian-Yong, Ge Zheng

Abstract excerpt

OBJECTIVE: Cytokine receptor-like factor 2(CRLF2) plays an important role in the development of normal B lymphocytes, which can mediate early B cell proliferation and survival. The aim of this study was to investigate the mutations of CRLF2 and its clinical significance in adult patients with acute lymphoblastic leukemia(ALL). METHODS: Exons of CRLF2 were amplified, then the DNA was purified and sequenced; the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to Mutation
Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prognosis

Share to Receptors, Cytokine

Source

Identifiers

PMID: 28446270
DOI: 10.7534/j.issn.1009-2137.2017.02.004

Genes

CRLF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Characteristics and Clinical Significance of CRLF2 Mutations in Adult Acute Lymphoblastic Leukemia].PMID 28446270Read ↗

Prognostic significance of CRLF2 overexpression and JAK2 mutation in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

Molecular characterization of acute lymphoblastic leukemia with high CRLF2 gene expression in childhoodSemantic proximity Read ↗

CRLF2-Positive B-Cell Acute Lymphoblastic Leukemia in Adult Patients: A Single-Institution Experience.Semantic proximity Read ↗

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.Semantic proximity Read ↗

Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemia.Semantic proximity Read ↗

[Gene Mutation in Acute Lymphoblastic Leukemia by DNA Sequencing].Semantic proximity Read ↗

[Mutation and expression of LEF1 in adult acute lymphocytic leukemia and their clinical significance].Semantic proximity Read ↗

IKZF1 alterations and expression of CRLF2 predict prognosis in adult Chinese patients with B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

[Relationship between IKZF3 Gene Single Nucleotide Polymorphisms and Childhood Acute Lymphoblastic Leukemia].Semantic proximity Read ↗

IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia.Semantic proximity Read ↗

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

CRLF2 and JAK2 in B-Progenitor Acute Lymphoblastic Leukemia: A Novel Association in OncogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.