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Article

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

1 Apr 2017

Abstract excerpt

While the HIV-1-glycan shield is known to shelter Env from the humoral immune response, its quantitative impact on antibody elicitation has been unclear. Here, we use targeted deglycosylation to measure the impact of the glycan shield on elicitation of antibodies against the CD4 supersite. We engineered diverse Env trimers with select glycans removed proximal to the CD4 supersite, characterized their structures...

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PMID: 28445724
DOI: 10.1016/j.celrep.2017.04.013

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