Article
Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions.
Structure (London, England : 1993) - 4 Aug 2020
Seabright Gemma E, Cottrell Christopher A, van Gils Marit J, D'addabbo Alessio, Harvey David J, Behrens Anna-Janina, Allen Joel D, Watanabe Yasunori, Scaringi Nicole, Polveroni Thomas M, Maker Allison, Vasiljevic Snezana, de Val Natalia, Sanders Rogier W, Ward Andrew B, Crispin Max
Abstract excerpt
Numerous broadly neutralizing antibodies (bnAbs) have been identified that target the glycans of the HIV-1 envelope spike. Neutralization breadth is notable given that glycan processing can be substantially influenced by the presence or absence of neighboring glycans. Here, using a stabilized recombinant envelope trimer, we investigate the degree to which mutations in the glycan network surrounding an epitope...
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