Article

Structural identification of neutralizing antibodies induced by nucleic acid encoded native-like trimer

2021-03-15

Abstract excerpt

<title>Abstract</title> <p>Despite extensive efforts, an efficacious HIV vaccine remains elusive. HIV Envelope (Env) is the target of all known neutralizing antibodies. Stabilizing Env into native-like trimer (NLT) conformations is required for recombinant protein immunogens to induce autologous neutralizing antibodies(nAbs) against difficult to neutralize HIV strains (tier-2) in rabbits and non-human primates. H...

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Literature Corpus work: 72060ee1-6e96-5683-a125-563334a49d82
DOI: 10.21203/rs.3.rs-275402/v1

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