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Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

11 May 2016

Abstract excerpt

HIV employs multiple means to evade the humoral immune response, particularly the elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies can act antivirally against a wide spectrum of viruses by targeting relatively conserved regions on the surface HIV envelope trimer spike. Elicitation of and recognition by bnAbs are hindered by the arrangement of spikes on virions and the...

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PMID: 27168247
DOI: 10.1146/annurev-immunol-041015-055515

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