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Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

2020-11-30

Abstract excerpt

The HIV-1 envelope glycoprotein trimer is poorly immunogenic because it is covered by a dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate antibody levels that neutralize clinically-relevant, neutralization-resistant (Tier-2) HIV-1 strains. Multivalent antigen presentation on nanoparticles is an established strategy to increase vaccine-driven immune responses. However, due...

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Identifiers and source

Literature Corpus work
79dcceb1-f249-5c9e-a694-ff0c1091d73e
DOI
10.1101/2020.11.30.403543
Open publication

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