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Article

Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6-Mercaptopurine Treatment.

Clinical and translational science - 1 Feb 2026

Khaeso Kanyarat, Chainansamit Su-On, Kuwatjanakul Pitchayanan, Komvilaisak Patcharee, Nakkam Nontaya, Suwannaying Kunanya, Vannaprasaht Suda, Dornsena Areerat, Tassaneeyakul Wichittra

Abstract excerpt

The nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) has been identified as a key genetic determinant of 6-mercaptopurine (6-MP)-induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of thiopurine S-methyltransferase (TPMT) variants. However, evidence remains limited in populations where both genetic variants are prevalent. This study aimed to...

Topics

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Antimetabolites, Antineoplastic
Infant
Mercaptopurine
Methyltransferases
Neutropenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyrophosphatases

Southeast Asian People

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Open in PubMed Open full text

Identifiers

PMID: 41560623
DOI: 10.1111/cts.70480
PMCID: PMC12820576

Genes

NUDT15
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6-Mercaptopurine Treatment.PMID 41560623Read ↗

NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine.Semantic proximity Read ↗

NUDT15 genetic variants are related to thiopurine-induced neutropenia in Thai children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Mercaptopurine induced myelosuppression in a child with a NUDT15 rs116855232 homozygous variant.Semantic proximity Read ↗

NUDT15 Polymorphism and Its Association With Mercaptopurine Hematotoxicity in Acute Lymphoblastic Leukemia in Indonesian Children.Semantic proximity Read ↗

Emerging role of NUDT15 polymorphisms in 6-mercaptopurine metabolism and dose related toxicity in acute lymphoblastic leukaemia.Semantic proximity Read ↗

Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.Semantic proximity Read ↗

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Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT 15 Genotypes: 2018 UpdateSemantic proximity Read ↗

Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age.Semantic proximity Read ↗

An integrated triple approach - TPMT phenotype, NUDT-15 genotype, and therapeutic drug monitoring of thiopurine metabolites for optimal clinical efficacy: a case series.Semantic proximity Read ↗

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