Article
Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance.
Alzheimer's research & therapy - 20 Jan 2024
Mei Hao, Simino Jeannette, Li Lianna, Jiang Fan, Bis Joshua C, Davies Gail, Hill W David, Xia Charley, Gudnason Vilmundur, Yang Qiong, Lahti Jari, Smith Jennifer A, Kirin Mirna, De Jager Philip, Armstrong Nicola J, Ghanbari Mohsen, Kolcic Ivana, Moran Christopher, Teumer Alexander, Sargurupremraj Murali, Mahmud Shamsed, Fornage Myriam, Zhao Wei, Satizabal Claudia L, Polasek Ozren, Räikkönen Katri, Liewald David C, Homuth Georg, Callisaya Michele, Mather Karen A, Windham B Gwen, Zemunik Tatijana, Palotie Aarno, Pattie Alison, van der Auwera Sandra, Thalamuthu Anbupalam, Knopman David S, Rudan Igor, Starr John M, Wittfeld Katharina, Kochan Nicole A, Griswold Michael E, Vitart Veronique, Brodaty Henry, Gottesman Rebecca, Cox Simon R, Psaty Bruce M, Boerwinkle Eric, Chasman Daniel I, Grodstein Francine, Sachdev Perminder S, Srikanth Velandai, Hayward Caroline, Wilson James F, Eriksson Johan G, Kardia Sharon L R, Grabe Hans J, Bennett David A, Ikram M Arfan, Deary Ian J, van Duijn Cornelia M, Launer Lenore, Fitzpatrick Annette L, Seshadri Sudha, Bressler Jan, Debette Stephanie, Mosley Thomas H
Abstract excerpt
BACKGROUND: Uncovering the functional relevance underlying verbal declarative memory (VDM) genome-wide association study (GWAS) results may facilitate the development of interventions to reduce age-related memory decline and dementia. METHODS: We performed multi-omics and pathway enrichment analyses of paragraph (PAR-dr) and word list (WL-dr) delayed recall GWAS from 29,076 older non-demented individuals of...
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