Article
Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets.
Diabetes - 1 Jul 2017
Li Changhong, Ackermann Amanda M, Boodhansingh Kara E, Bhatti Tricia R, Liu Chengyang, Schug Jonathan, Doliba Nicolai, Han Bing, Cosgrove Karen E, Banerjee Indraneel, Matschinsky Franz M, Nissim Itzhak, Kaestner Klaus H, Naji Ali, Adzick N Scott, Dunne Mark J, Stanley Charles A, De León Diva D
Abstract excerpt
Loss-of-function mutations of β-cell KATP channels cause the most severe form of congenital hyperinsulinism (KATPHI). KATPHI is characterized by fasting and protein-induced hypoglycemia that is unresponsive to medical therapy. For a better understanding of the pathophysiology of KATPHI, we examined cytosolic calcium ([Ca2+] i ), insulin secretion, oxygen consumption, and [U-13C]glucose metabolism in islets...
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