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Article

K(ATP) channels and insulin secretion disorders.

American journal of physiology. Endocrinology and metabolism - 1 Aug 2002

Huopio H, Shyng S-L, Otonkoski T, Nichols C G

Abstract excerpt

ATP-sensitive potassium (K(ATP)) channels are inhibited by intracellular ATP and activated by ADP. Nutrient oxidation in beta-cells leads to a rise in [ATP]-to-[ADP] ratios, which in turn leads to reduced K(ATP) channel activity, depolarization, voltage-dependent Ca(2+) channel activation, Ca(2+) entry, and exocytosis. Persistent hyperinsulinemic hypoglycemia of infancy (HI) is a genetic disorder characterized by...

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Identifiers

PMID: 12110524
DOI: 10.1152/ajpendo.00047.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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