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Article

CYP3A4 and CYP3A5 Genes in Cyclophosphamide-treated Chronic Lymphocytic Leukemia Patients: A Pharmacogenetics Study.

Frontiers in bioscience (Scholar edition) - 26 Jun 2025

Elmaraghy Heba M, Al-Adl Menna, Saifeldein Eman R, Elashmony Sahar M, Youssef Magdy M, El-Said Afaf, Refaat Sherif, Mohammed Abdallah E

Abstract excerpt

BACKGROUND: Approximately 75% of drug metabolism in clinical settings is attributed to cytochrome P450 enzymes. This study aimed to assess the effects of the CYP3A4*1B and CYP3A5*3 genetic variations on the clinical results of individuals with chronic lymphocytic leukemia (CLL) following cyclophosphamide treatment. Furthermore, we aimed to ascertain how well the inflammatory condition affects the therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

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Share to Interleukin-6

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 40613206
DOI: 10.31083/FBS36269

Genes

CYP3A4
CYP3A5
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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