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Ets1 Controls the Development of B Cell Autoimmune Responses in a Cell-Intrinsic Manner

1 Jul 2019

Abstract excerpt

Abstract Ets1 is emerging as a key transcription factor that is required to prevent autoimmunity in mice and humans. Ets1 is expressed in both B and T cells, and mice lacking Ets1 are characterized by excess B and T cell activation, leading to enhanced formation of Ab-secreting cells and high titers of autoantibodies. In humans, genome-wide association studies have detected associations of single nucleotide...

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PMID: 31356162
DOI: 10.4049/immunohorizons.1900033

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