Functional human GRIN2B promoter polymorphism and variation of mental processing speed in older adults.

doi:10.18632/aging.101228

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Functional human GRIN2B promoter polymorphism and variation of mental processing speed in older adults.

Aging - 1 Apr 2017

Jiang Yang, Lin Ming Kuan, Jicha Gregory A, Ding Xiuhua, McIlwrath Sabrina L, Fardo David W, Broster Lucas S, Schmitt Frederick A, Kryscio Richard, Lipsky Robert H

Abstract excerpt

We investigated the role of a single nucleotide polymorphism rs3764030 (G>A) within the human GRIN2B promoter in mental processing speed in healthy, cognitively intact, older adults. In vitro DNA-binding and reporter gene assays of different allele combinations in transfected cells showed that the A allele was a gain-of-function variant associated with increasing GRIN2B mRNA levels. We tested the hypothesis that...

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PMID: 28439047
DOI: 10.18632/aging.101228
PMCID: PMC5425128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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