Article
Rare genetic variants correlate with better processing speed.
Neurobiology of aging - 1 May 2023
Song Zeyuan, Gurinovich Anastasia, Nygaard Marianne, Mengel-From Jonas, Andersen Stacy, Cosentino Stephanie, Schupf Nicole, Lee Joseph, Zmuda Joseph, Ukraintseva Svetlana, Arbeev Konstantin, Christensen Kaare, Perls Thomas, Sebastiani Paola
Abstract excerpt
We conducted a genome-wide association study of Digit Symbol Substitution Test scores administered in 4207 family members of the Long Life Family Study (LLFS). Genotype data were imputed to the HRC panel of 64,940 haplotypes resulting in ∼15M genetic variants with a quality score > 0.7. The results were replicated using genetic data imputed to the 1000 Genomes phase 3 reference panel from 2 Danish twin cohorts:...
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