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Article

MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.

Oncogene - 24 Aug 2017

von Morgen P, Burdova K, Flower T G, O'Reilly N J, Boulton S J, Smerdon S J, Macurek L, Hořejší Z

Abstract excerpt

The MRN (MRE11-RAD50-NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts with PIH1D1, a subunit of heat-shock protein 90 cochaperone R2TP complex, which is required for the assembly of large...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28436950
DOI: 10.1038/onc.2017.99
PMCID: PMC5531254

Genes

MRE11
PIH1D1
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.PMID 28436950Read ↗

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