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Article

Rad50 depletion impacts upon ATR-dependent DNA damage responses.

Human molecular genetics - 15 Sept 2005

Zhong Hui, Bryson Alyson, Eckersdorff Mark, Ferguson David O

Abstract excerpt

The Mre11/Rad50/NBS1 (MRN) complex is mutated in inherited genomic instability syndromes featuring cancer predisposition, mental retardation and immunodeficiency. It functions both in DNA double-strand break repair and in controlling the ataxia telangiectasia mutated (ATM) kinase during the response to these lesions. Patients inheriting homozygosity for an NBS1 hypomorphic allele display reduced phosphorylation...

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Source

Identifiers

PMID: 16087684
DOI: 10.1093/hmg/ddi302

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rad50 depletion impacts upon ATR-dependent DNA damage responses.PMID 16087684Read ↗

The Mre11-Rad50-Nbs1 Complex Acts Both Upstream and Downstream of Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR) to Regulate the S-phase Checkpoint following UV TreatmentSemantic proximity Read ↗

Human RAD50 deficiency: Confirmation of a distinctive phenotype.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

NBS1 and its functional role in the DNA damage response.Semantic proximity Read ↗

Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.Semantic proximity Read ↗

A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin.Semantic proximity Read ↗

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The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and RepairSemantic proximity Read ↗

Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis.Semantic proximity Read ↗

Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair.Semantic proximity Read ↗

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.Semantic proximity Read ↗

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN ComplexSemantic proximity Read ↗

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