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Article

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.

Cells - 13 Jul 2020

Rahman Samiur, Canny Marella D, Buschmann Tanner A, Latham Michael P

Abstract excerpt

The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability within the cell. The role of the MRN complex to recognize and process DNA double-strand breaks as well as signal other damage response factors is critical for maintaining proper cellular function. Mutations in any one of the components of the MRN complex that...

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Identifiers

PMID: 32668560
DOI: 10.3390/cells9071678
PMCID: PMC7407228

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A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.PMID 32668560Read ↗

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