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Article

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response

31 Aug 2016

Abstract excerpt

Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells. Here, we functionally characterize C5orf45 as a binding partner of the MRE11-RAD50-NBS1 (MRN) damage-sensing complex. Hence, we rename C5orf45 as MRNIP for MRN-interacting protein (MRNIP). We...

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PMID: 27568553
DOI: 10.1016/j.celrep.2016.07.087

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