Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.

doi:10.1038/s41598-017-01098-4

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Article

Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.

Scientific reports - 21 Apr 2017

Polimanti Renato, Jensen Kevin P, Gelernter Joel

Abstract excerpt

To identify novel phenotypic associations related to Cytochrome P450 Family 2 Subfamily A Member 6 (CYP2A6), we investigated the human phenome in a total of 11,271 individuals. Initially, we conducted a phenome-wide association study in 3,401 nicotine-exposed elderly subjects considering 358 phenotypic traits. We identified a significant association between CYP2A6 rs113288603 and hearing loss symptoms...

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Identifiers

PMID: 28432340
DOI: 10.1038/s41598-017-01098-4
PMCID: PMC5430682

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