Article
CYP2B6 gene single-nucleotide polymorphisms in an Italian population sample and relationship with nicotine dependence.
Genetic testing and molecular biomarkers - 1 Feb 2015
Riccardi Laura Natalia, Carano Francesco, Bini Carla, Ceccardi Stefania, Ferri Gianmarco, Pelotti Susi
Abstract excerpt
The extensively polymorphic CYP2B6 gene metabolizes endogenous and exogenous compounds, among which are nicotine and bupropion, although its contribution to the systemic metabolism of nicotine still remains controversial. In the present study, the distribution of the CYP2B6 variant and genotype frequencies were analyzed in a sample of 202 Italian individuals who were also invited to answer the Fagerström test for...
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