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Article

The first genome-wide association study identifying new susceptibility loci for obstetric antiphospholipid syndrome.

Journal of human genetics - 1 Sept 2017

Sugiura-Ogasawara Mayumi, Omae Yosuke, Kawashima Minae, Toyo-Oka Licht, Khor Seik-Soon, Sawai Hiromi, Horita Tetsuya, Atsumi Tatsuya, Murashima Atsuko, Fujita Daisuke, Fujita Tomio, Morimoto Shinji, Morishita Eriko, Katsuragi Shinji, Kitaori Tamao, Katano Kinue, Ozaki Yasuhiko, Tokunaga Katsushi

Abstract excerpt

Antiphospholipid syndrome (APS) is the most important treatable cause of recurrent pregnancy loss. The live birth rate is limited to only 70-80% in patients with APS undergoing established anticoagulant therapy. Lupus anticoagulant (LA), but not anticardiolipin antibody (aCL), was found to predict adverse pregnancy outcome. Recent genome-wide association studies (GWAS) of APS focusing on aCL have shown that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28424481
DOI: 10.1038/jhg.2017.46

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TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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